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Discover the hyperbaric medicine center opened in our clinic. Centrokinetic has the top-performing hyperbaric chamber in Bucharest, with multiple medical and anti-aging uses. The Baroks chamber has 5 seats, and operates at a constant pressure of 2.5 atmospheres, being fully automated and having protocols for each condition, and can be used individually for each patient.
Hyperbaric oxygen therapy - benefits
Patients who use the clinic's hyperbaric therapy services benefit from:
- The only medically accredited hyperbaric therapy chamber in Bucharest, which operates at 2.5 atmospheres (those for aesthetic use go to 1 atmosphere and have no medical benefits).
- A safe medical procedure, without irradiation, without pain, without other side effects.
- The specialized medical team consists of recovery doctors, orthopedists, rheumatologists, neurologists, and neurosurgeons, meaning a multidisciplinary team specialized in all diseases that can be treated with hyperbaric therapy.
- Premium conditions at a fair price. Our clinic is recognized for the conditions offered and for the care of each patient. But we do not need to pay exorbitant prices to have access to quality medical services. At Centrokinetic you can find an affordable and fair price. But note that we do not have a contract with the National Health Insurance House (we do not offer state reimbursed services)
Centrokinetic is keeping contact with prestigious clinics and universities in Belgium, the Netherlands, France, and Greece to constantly update treatments to provide patients with the best medical solutions.
What is osteoradionecrosis?
Osteoradionecrosis (ORN) is a common consequence of radiation provided to cancer patients. Currently, hyperbaric oxygen therapy (HBOT) has a major role in improving wound healing in patients with ORN. There is no strong scientific evidence to confirm the benefits of HBOT for ORN treatment as an adjunct treatment. This study aimed to determine the benefits of additional HBOT treatment in ORN. A retrospective study was conducted at Srinagarind Hospital, along with the Khon Kaen Faculty of Medicine, Thailand, on data collected between 2011 and 2017.
Osteoradionecrosis (ORN) is a common consequence of radiation in cancer patients. The most commonly affected bone is the mandible. Patients with this malignancy generally receive conventional therapy, including surgery, chemotherapy, and radiation therapy. Various forms of ionizing radiation have been used to treat cancer. Also, ionizing radiation almost certainly harms soft and hard tissues. As a result, the affected soft tissues were damaged and this caused progressive endarteritis and fibrosis. These lead to ischemia of the affected tissues. Similarly, these side effects occurred in the bone, destroying local vascular systems and cellular components.
There are several treatment modalities to improve wound healing in patients with ORN. Both conservative and modern treatments are used to improve the healing process of ORN. Currently, hyperbaric oxygen therapy (HBOT) plays a role in treating wounds in patients with ORN. HBOT may be used as an adjunctive treatment for surgery to accelerate the healing process in patients with ORN. Further studies on the effects of HBOT are needed to support the benefits of its use in ORN patients.
Materials and methods
The idea of this study was to determine the influence of HBOT in patients with ORN. This study was conducted from 2011 to 2017 at Srinagarind Hospital by Khon Kaen University in Thailand. 84 patients were included in this study. The inclusion criteria for this study were all patients with ORN who received HBOT as an adjunctive prophylactic treatment before and after the procedure.
All patients had evidence of previous radiation therapy for head and neck cancer. The criteria for staging were the following:
- Stage 1 represented by bones exposed to radiotherapy but asymptomatic
- Stage 2 was represented by patients with bones exposed to radiotherapy and symptoms such as pain, soft tissue inflammation, or even infection.
- Stage 3 was represented by patients with symptoms and signs similar to those in stage 2, combined with pathological fracture or skin fistula.
Medical history, physical examination, and plain radiography were performed in all patients with uncomplicated conditions, and those patients with severe manifestations required a computed tomography, especially those in stage 3. The main result of the study was wound healing which was defined by the complete coverage of soft tissues, without any infection, inflammatory process or fistula. Evaluation of wound healing was documented after treatment and at least a 6-month break to examine the patient's condition in the absence of the disease.
All patient demographics and clinical data were recorded, including age, sex, primary cancer types, ORN stages, surgical procedures, HBO therapy (total oxygenation time and number of treatments applied) and wound healing outcome. As a treatment protocol, patients were treated daily with HBO before surgery and after surgery. If, however, the wound did not heal, an extension of treatment was considered. Also, patients were treated daily with HBO at 2.4 absolute atmospheres for 90 min. The surgical procedure for patients with stage 1 and 2 ORN was tooth extraction, while stage 3 was bone debridement.
The generalized linear model (GLM) was used to determine the correlation between variables and HBOT treatment outcomes. This model was used to determine significant variables that were independently associated with HBOT. Poisson regression was used to correct GLM overuse using the Bootstrapping, as the number of HBOTs can vary. HBOT outcomes were adjusted for age, sex, primary cancer, and ORN stages.
This study was approved by the Ethics Committee of Khon Kaen University for Human Research (HE611060).
What are the effects of oxygen therapy on the body?
- Decreases inflammation
- Increases the body's oxygen saturation by 20-30%
- Increases the body's immunity
- Increases blood circulation and stimulates the formation of new capillaries
- Decreases toxins in the body
- Stimulates the production of new blood cells
- Increases healing rate
84 patients with ORN were included in this study. The mean age of the patients included in this study was 58-78 years. Both sexes were included almost equally (54.76% were men and 45.24% were women). Also, the average number of total HBOT treatments was 29.83. Most patients had primary oral cancer (70.24%), followed by cancer of the nasopharynx (23.81%) and cancer of the throat (5.95%). Also, most patients were in stage 1, more precisely 63.10%, only 8.33% of patients were in stage 2, and in stage 3, were 28.57% of patients.
Univariate analysis was performed, and the results revealed that there was only one significant variable that was associated with the number of HBOT treatments, resulting in healed wounds. The regression analysis of the effects showed that stage 3 of the ORN was negatively correlated with the number of HBOT treatments. Multivariate analysis showed the same results, showing that HBOT therapy has a beneficial effect on patients with ORN.
ORN is a complication of radiation therapy in head and neck cancer. ORN creates a problem for a complex therapeutic process, such as tissue transfer. The results of the treatment are often not as expected, and an unfavorable outcome may occur. Some procedures, such as tooth extraction or even debridement, can cause a progression of the ORN. The doctor must consider the prevention protocols before performing specific procedures on the jaw. Currently, several previous studies have highlighted that HBOT has a significant role in treating patients with ORN.
Patients with ORN included in this study were treated with HBOT as adjunctive and prophylactic treatment. This study determined the outcome of HBOT treatment. Poisson regression analysis showed that in stage 3 of the ORN patients had very good results from HBOT treatment, which led to a wound healed analyzed using both univariate and multivariate analyzes. Significantly, stage 3 required a lower number of HBOT treatments compared to stage 2, because stage 3 patients had already undergone bone debridement, while bone debridement was not performed in stage 2 disease. Stage 3 ORN has severe bone necrosis and has a more severe manifestation than stage 2. Consequently, patients with stage 3 ORN have performed bone debridement before or bone resection.
There is still controversy over the use of HBOT in ORN. Also, it was found that stage 1 of the ORN also required a small number of HBOT treatments because the lesion was in an early and less severe stage. HBOT was effective in stage 1. Therefore, patients with stage 1 ORN could be cured simply by treatment with a small number of HBO treatments without surgery.
The most appropriate treatment for stage 2 patients who have less bone necrosis compared to stage 3 has often been difficult to plan because the lesion is not severe enough to require early surgery, which includes bone debridement or bone resection. Therefore, these patients can be cured with conservative treatment. Stage 2 patients needed a large number of HBOT treatments for effective wound healing. These results show that the success rate of HBOT at this stage is not as high as in the first and third stages.
In contrast, if patients with stage 2 ORN undergo an early bone debridement or bone resection process and are subsequently treated with HBO, they will gain a greater clinical advantage compared to delayed surgery. Therefore, surgical therapy should be considered early for patients with ORN in stages 2 and 3 to heal the wounds and reduce the length of hospital stay for HBOT treatment.
HBOT has played a significant role in improving wound healing in patients with ORN in stages 1 and 3. Also, patients with stage 2 diabetes significantly required the highest number of HBOT treatments compared to other types of ORN for the effects of this technique to be seen in wound healing, while stage 3 patients who have gone through the process of bone debridement have had the highest success rate following HBOT treatments. Bone debridement essentially improves wound healing in ORN patients with severe manifestations, leading to the use of fewer HBOT treatments.
IN CASE YOU HAVEN'T ALREADY HEARD ABOUT US
Centrokinetic is the place where you will find clear answers and solutions for your motricity problems. The clinic is dedicated to osteoarticular diseases and is divided into the following specialized departments:
- Orthopedics , a department composed of an extremely experienced team of orthopedic doctors, led by Dr. Andrei Ioan Bogdan, primary care physician in orthopedics-traumatology, with surgical activity at Medlife Orthopedic Hospital, specialized in sports traumatology and ankle and foot surgery. .
- Pediatric orthopedics , where children's sports conditions are treated (ligament and meniscus injuries), spinal deformities (scoliosis, kyphosis, hyperlordosis) and those of the feet (hallux valgus, hallux rigidus, equine larynx, flat valgus, hollow foot).
- Neurology , which has an ultra-performing department, where consultations, electroencephalograms (EEG) and electromyography (EMG) are performed.
- Medical recovery for adults and children , department specialized in the recovery of performance athletes, in spinal disorders, in the recovery of children with neurological and traumatic diseases. Our experience is extremely rich, treating over 5000 performance athletes.
- Medical imaging , the clinic being equipped with ultrasound and MRI, high-performance devices dedicated to musculoskeletal disorders, and complemented by an experienced team of radiologists: Dr. Sorin Ghiea and Dr. Cosmin Pantu, specialized in musculoskeletal imaging.
Hyperbaric oxygen therapy in intestinal pneumatosis
Cystoid or cystic intestinal pneumatosis (intestinal emphysema) is a symptom that can occur in many gastrointestinal diseases. Hyperbaric oxygen therapy can be a successful treatment of cystoid intestinal pneumatosis and granulomatosis with polyangiitis.READ MORE
Hyperbaric oxygen therapy in cell damage caused by radiation in gynecological cancers
Gynecological cancers treated with a combination of external beam radiation and brachytherapy, especially cervical and vaginal cancers, can result in the apex of the vagina receiving a high dose of radiation. Hyperbaric oxygen therapy has positive effects on the radiated tissues, especially the head, neck, anus, and rectum.READ MORE
Hyperbaric oxygen therapy in post-radiotherapy CNS injury
Hyperbaric oxygen therapy involves the use of so-called levels of oxygen under pressure to increase the level of oxygen in the blood. The use of hyperbaric oxygen therapy involves oxygen treatment for soft tissue radionecrosis. Read this article and find out more.READ MORE
Hyperbaric oxygenation vs normobaric oxygenation in CO poisoning
Prolonged CO exposure is responsible for more than half of fatal poisonings and is also one of the leading causes of poisoning in Western countries. We aimed to compare the effectiveness of therapy with hyperbaric oxygen (HBO) versus normobaric oxygen (NBO) in the setting of carbon monoxide poisoning (COP).READ MORE
Hyperbaric oxygen therapy in diabetic foot
Hyperbaric oxygen therapy may be effective for Wagner's grade 3 and 4 diabetic foot ulcers and need to study the real problems with patients seeking treatment and demonstrates the need to study the real problems with patients seeking treatment. The results show that it is important to follow the treatment in order for the HBOT to be efficient.READ MORE
The role of hyperbaric oxygen therapy in sports medicine
Hyperbaric oxygen is used in sports medicine to reduce hypoxia and edema and is also effective in treating stroke injuries and acute traumatic peripheral ischemia. When used clinically, hyperbaric oxygen should be considered as an adjuvant therapy used as early as possible after the diagnosis of the lesions.READ MORE
Hyperbaric oxygen therapy in muscle injuries
Muscle stretches are the most common muscle injuries suffered during performance sports. Rapid recovery from muscle injury is crucial for elite athletes who regularly are exposed to training and increased competition. Hyperbaric oxygen therapy is a safe and effective method, being a non-invasive treatmentREAD MORE
Hyperbaric oxygen therapy in sports injuries
Hyperbaric therapies are methods used to treat disease or injury using pressures higher than the local atmospheric pressure inside a hyperbaric chamber. The long-term effects are neovascularization (angiogenesis in hypoxic soft tissues), osteoneogenesis, and stimulation of collagen production by fibroblasts. This is beneficial for wound healing and recovery after irradiation.READ MORE
Hyperbaric oxygen therapy in proctitis generated by radiation
Proctitis is the inflammation of the rectal mucosa causing pain, discharge, and other unusual symptoms. Pain can occur during bowel movements, it can be acute or chronic. Symptoms may vary, but the most common is tenesmus (the feeling of needing to go to the toilet), a sensation that persists even after using the toilet. This treatment should be offered to patients who fail to recover with conventional treatments for radiation-induced proctitis.READ MORE
Hyperbaric oxygen therapy in refractory osteomyelitis
Osteomyelitis is an infection of the bone or marrow caused by bacteria or mycobacteria. Hyperbaric oxygen treatments can be considered an American Heart Association (AHA) Class II recommendation for the treatment of chronic, refractory osteomyelitisREAD MORE
Hyperbaric oxygen therapy in tinnitus
Hyperbaric oxygenation allows a controlled increase in oxygen pressure in the blood. This technique can be used in cases of tinnitus and sudden deafness, when certain changes in the inner ear and brain generate a lack of oxygen and, therefore, a limited intake of energy.READ MORE
Hyperbaric oxygen therapy of ischemia and reperfusion injury
Hyperbaric oxygen therapy has been found to ameliorate the damaging effects of reperfusion by early modulation of inflammation, maintenance of metabolic function in downstream tissues, and reintroduction of oxidation scavengers.READ MORE
Hyperbaric therapy in the treatment of second degree burns
HBOT has a beneficial effect on burn wound healing by reducing edema and ensuring there is adequate oxygen in microcirculation. It may speed up epithelialization and suppress unnecessary inflammation that could negatively affect normal wound healing. With further research, HBOT may become an adjuvant therapy to surgery.READ MORE
Hyperbaric oxygen therapy in the management of patients with malignant otitis externa
Malignant otitis externa is a rapidly spreading bacterial infection that is aggressive and may be fatal if left untreated. Hyperbaric oxygen therapy (HBOT) is a medical treatment in which the entire body is placed in an airtight chamber at increased atmospheric pressure and has been proven to be effective for several different medical conditions.READ MORE
Hyperbaric oxygen therapy in acute myocardial infarction
If left untreated, MI will lead to the progressive loss of viable cardiomyocytes, impaired heart function, and congestive heart failure. Oxygen cycling therapy serves as a very attractive option for the treatment of myocardial infarction, because it offers some of the greatest benefits while reducing treatment time and inconvenience to the subject.READ MORE
Hyperbaric oxygen in ischemic ulcers
The present study has demonstrated that adjunct HBOT enhances the reduction of ulcer area and depth at 4 weeks in T2DM patients with ischaemic DFUs. HBOT is known to ensure hyperoxygenation of ischaemic tissue and restoration from hypoxia. Discover the hyperbaric medicine center open in our clinic. Centrokinetic has the top-performing hyperbaric chamber in Bucharest.READ MORE
Hyperbaric therapy in femoral condylar osteonecrosis
Osteonecrosis of the knee (ONK) is a form of aseptic necrosis resulting from ischemia to subchondral bone tissue. Typically, treatment is invasive. Hyperbaric oxygen therapy (HBOT) may provide a noninvasive alternative by improving oxygenation and reperfusion of ischemic areas. This study evaluates the efficacy of HBOT in a series of ONK patients.READ MORE
Hyperbaric therapy in femoral head necrosis
Femoral head necrosis (FHN), also called avascular necrosis, or femoral head osteonecrosis is a common multifactorial condition that affects patients of any age and can lead to substantial clinical morbidity. Hyperbaric oxygen therapy (HBO) is one of the proposed treatments. Indeed, tissue oxygen promotes angiogenesis that reduces edema. Read about the effectiveness of this treatment.READ MORE
Hyperbaric oxygen therapy in central retinal artery occlusion
Central retinal artery occlusion (CRAO) is a devastating and common eye condition. It presents a sudden, unilateral, and painless loss of vision. Even when treated promptly, an acute obstruction of the central retinal artery usually leads to severe and permanent loss of vision.READ MORE
Hyperbaric therapy in irradiated maxillofacial dental implant
There are numerous studies reported for the effectiveness of HBO in the treatment of osteoradionecrosis of various bone tissues. In addition to its usefulness in treating osteoradionecrosis, this therapy can prevent it. It also combats the negative effect of irradiation, stimulates osseointegration, and improves the survival rate of the implant.READ MORE
Hyperbaric oxygen therapy in hear loss
The auditory function in the inner ear is maintained by the cochlea, which is known to have a high oxygen demand. Hyperbaric oxygen can increase the tension of oxygen in the perilymph and restore hearing in a significant number of patients with sudden hearing loss. Patients can be treated in a single-seater hyperbaric chamber or in a multiplace chamber.READ MORE
Hyperbaric therapy in traumatic ischemia
Limb trauma, which leads to direct tissue damage, plus local hypoxic disorders caused by the resulting edema, causes acute peripheral ischemia. Surgical treatment and hyperbaric oxygen are not concurrent treatment modalities but are best used to complement each other in order to provide the best outcome for the patient.READ MORE
Hyperbaric therapy in venous embolism
Small gas embolisms, as in this case, present serious risks, especially the complication of cerebral air embolism. To prevent neurological complications, it is necessary to urgently remove the air bubble. HBOT reduces the volume of the bubble, helps eliminate nitrogen, and improves the oxygenation of potentially hypoxic tissue. See the results of hyperbaric therapy in venous embolism.READ MORE
Hyperbaric oxygen therapy in soft tissue radionecrosis
Discover the hyperbaric medicine center open in our clinic. Centrokinetic has the top-performing hyperbaric chamber in Bucharest, with multiple medical and anti-aging uses. The Baroks chamber has 5 seats, and operates at a constant pressure of 2.5 atmospheres, being fully automated and having protocols for each condition, and can be used individually for each patient.READ MORE
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